[Correlation of cardiovascular risk factors versus glomerular filtration rate in healthy population]

Abstract

Objective: To evaluate the relationship between cardiovascular risk factors and glomerular filtration rate in healthy population.

Methods: A community-based cross-sectional study was conducted in Shenyang. The Framingham sex-specific risk equation was employed to evaluate the cardiovascular risk factors of 501 healthy study objects, calculate Framingham risk score and estimate the risk of 10-year coronary heart disease (CHD). A total of 501 study subjects were then divided into 3 groups according to 10-year CHD risk: low risk group (< 10%), moderate risk group (10% -20%) and high risk group ( > 20%). Study subjects were also divided into 5 groups according to age: < or = 44 years old; 45 - 54 years old; 55 - 64 years old; 65 - 74 years old and > or = 75 years old. The Cockcroft-Gault equation (GFR(CG)), abbreviated MDRD equation (GFR(MDRD1)) and modified MDRD equation (GFR(MDRD2)) were used to estimate glomerular filtration rate (GFR). Glomerular filtration rate (GFR) were compared among different risk groups and correlation coefficients between Framingham risk score and glomerular filtration rate calculated.

Results: GFR(CC), GFR(MDRD1) and GFR(MDRD2) in the low risk group was [(103 +/- 27) ml x min(-1) GFR(MDRD2) in moderate risk group all decreased [(84 +/- 24) ml x min(-1) x (1.73 m2) (-1), (101 +/- 27) ml x min(-1) x (1.73 m2) (-1), (124 +/- 33)ml x min(-1) (1.73 m2) (-1), all P < 0.01]. GFR(CG), GFR(MDRD1) and GFR(MR(MDRD2) in the high risk group all decreased [(71 +/- 15) ml x min(-1) (1.73 m2) (-1), (88 +/- 15) ml x min(-1) x (1.73 m2)(-1), (109 +/-18)ml x min(-1) x (1.73 m2) (-1), all P < 0.01]. The GFR(CG), GFR(MDRD1) and GFR(MDRD2) in the high risk group all decreased compared with the moderate risk group (P < 0.05). There was a significantly inverse correlation between Framingham risk score and GFR with the Pearson correlation coefficient -0.586 (GFR(CG), P < 0.01) and -0.449 (GFR(MDRD1) and GFR(MDRD2), P < 0.01).

Conclusion: There is an inverse correlation between cardiovascular risk factors and GFR in healthy population. With the increasing of risk factors and their severity, Framingham risk score increases and GFR decreases.