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Review
. 2009 Dec;10(12):1897-903.
doi: 10.2217/pgs.09.134.

Drug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy

Navin Pinto  1 , Susan M Ludeman, M Eileen Dolan
Affiliations
Review

Drug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy

Navin Pinto et al. Pharmacogenomics. 2009 Dec.

Abstract

Cyclophosphamide is a cornerstone in the treatment of many pediatric and adult malignancies, as well as in the treatment of refractory autoimmune conditions. Genetic factors are thought to play a role in the interindividual variation in both response and toxicities associated with cyclophosphamide-based therapies. This drug focus reviews the most compelling studies conducted on the pharmacogenetics of cyclophosphamide-based therapies. Broader pharmacogenomic studies are needed and may reveal additional factors important in susceptibility to toxicity and/or response to therapy.

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