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. 1991 Jan;91(1):59-64.
doi: 10.1530/jrf.0.0910059.

1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells

A Halhali  1 , G M Acker, M Garabédian
Affiliations

1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells

A Halhali et al. J Reprod Fertil. 1991 Jan.

Abstract

Intraluminal injection of female rats at Day 5 of pseudopregnancy with 10-500 ng 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) significantly increased the uterine weight and induced decidual reaction. This effect was observed as early as the 3rd day after 1,25-(OH)2D3 injection. It was detectable only in the injected left horn and not in the non-injected right horn. A 500 ng dose of 25-(OH)D3 had no such effect. The present in-vivo results suggest that 1,25-(OH)2D3 may play a physiological role in endometrial cell differentiation into decidual cells, a crucial step in the process of blastocyst implantation.

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