Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009:2009:937352.
doi: 10.1155/2009/937352. Epub 2009 Apr 14.

Aspirin resistance

Khaled Mansour  1 , Ali T Taher, Khaled M Musallam, Samir Alam
Affiliations

Aspirin resistance

Khaled Mansour et al. Adv Hematol. 2009.

Abstract

The development of adverse cardiovascular events despite aspirin use has established an interest in a possible resistance to the drug. Several definitions have been set and various laboratory testing modalities are available. This has led to a wide range of prevalence reports in different clinical entities. The etiologic mechanism has been related to clinical, genetic, and other miscellaneous factors. The clinical implications of this phenomenon are significant and warrant concern. Management strategies are currently limited to dosing alteration and introduction of other anitplatelet agents. However, these measures have not met the expected efficacy or safety.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Proposed factors contributing to aspirin resistance (CABG: coronary artery bypass grafting; COX: cyclooxygenase; NSAIDS: nonsteroidal anti-inflamatory drugs; PPI: proton pump inhibitors).
Figure 2
Figure 2
Algorithm highlighting approach to a patient with suspected aspirin resistance. ACS: acute coronary syndrome; NSAIDs: nonsteroidal antiinflamatory drugs; PPI: proton pump inhibitors; CAD: coronary artery disease; MI: myocardial infarction; PVD: peripheral vascular disease; LTA: light transmittance aggregometry; PFA: platelet function analyzer.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. The Second International Study of Infarct Survival Collaborative Group. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. The Lancet. 1988;2(8607):349–360. - PubMed
    1. Antithrombotic Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy—II: maintenance of vascular graft or arterial patency by antiplatelet therapy. British Medical Journal. 1994;308(6922):159–168. - PMC - PubMed
    1. Antithrombotic Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy—III: reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. British Medical Journal. 1994;308(6923):235–246. - PMC - PubMed
    1. Baigent C, Sudlow C, Collins R, Peto R. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. British Medical Journal. 2002;324(7329):71–86. - PMC - PubMed
    1. Marson P, Pasero G. The Italian contributions to the history of salicylates. Reumatismo. 2006;58(1):66–75. - PubMed

LinkOut - more resources