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. 2007 Mar 2;56(4):489-496.
doi: 10.1002/pi.2230.

Dendrimers as drug delivery vehicles: non-covalent interactions of bioactive compounds with dendrimers

Hannah L Crampton  1 , Eric E Simanek
Affiliations

Dendrimers as drug delivery vehicles: non-covalent interactions of bioactive compounds with dendrimers

Hannah L Crampton et al. Polym Int. .

Abstract

This mini review highlights issues associated with the use of dendrimers as drug delivery vehicles. The review introduces dendrimers and summarizes findings on their use in vivo and in vitro. Specifically, this review is limited to examples wherein the drug is non-covalently associated with the dendrimer. Examples wherein the drug is covalently attached to the dendrimer are not discussed.

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Figures

Figure 1
Figure 1
Generalized generation-3 dendrimer. C = core, B = branching points, O = outer surface groups.
Figure 2
Figure 2
Schematic of the EPR effect.
Figure 3
Figure 3
Poly(ethylene glycol) shields the ionizable dendrimer groups.
Figure 4
Figure 4
Fractured PAMAM dendrimer Superfect®.
Figure 5
Figure 5
Schematic of dendrimer-bound DNA.
Figure 6
Figure 6
Dendrimer containing phthalocyanin.
Figure 7
Figure 7
(a) Generation-3 PAMAM dendrimer and (b) several drugs that interact with its surface.
Figure 8
Figure 8
Methotrexate and adriamycin.
Figure 9
Figure 9
Anticancer drug paclitaxel.
Figure 10
Figure 10
Generation-3 polyglycerol dendrimer.
See this image and copyright information in PMC

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