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Review
. 2009 Dec 7;15(45):5633-40.
doi: 10.3748/wjg.15.5633.

Emerging role of microRNAs in liver diseases

Shashi Bala  1 , Miguel Marcos, Gyongyi Szabo
Affiliations
Review

Emerging role of microRNAs in liver diseases

Shashi Bala et al. World J Gastroenterol. .

Abstract

MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apoptosis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules.

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Figures

Figure 1
Figure 1
Various modes of gene regulation by miRNAs.
See this image and copyright information in PMC

References

    1. Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science. 2002;297:1833–1837. - PubMed
    1. Voinnet O. Induction and suppression of RNA silencing: insights from viral infections. Nat Rev Genet. 2005;6:206–220. - PubMed
    1. Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science. 2005;309:1519–1524. - PubMed
    1. Ambros V. The functions of animal microRNAs. Nature. 2004;431:350–355. - PubMed
    1. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843–854. - PubMed

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