Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Jun 15;5(3):212-4.

Strong chemoreflex modulation of sleep-breathing: some answers but even more questions

Robert J Thomas  1
Affiliations
Comment

Strong chemoreflex modulation of sleep-breathing: some answers but even more questions

Robert J Thomas. J Clin Sleep Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Detection of strong chemoreflex modulation of sleep-breathing at simulated altitude: Pre (left) and post (middle) 14 days of 13,000 feet simulated altitude. High altitude induced sleep-disordered breathing is a relatively pure example of a chemoreflex mediated disorder. The sleep spectrogram detects narrow band coupling in all new sleep-disordered breathing at simulated altitude. Note the shift from high (“up” arrow) to low frequency (“down” arrow) coupling. Two characteristics of altitude-induced sleep apnea increase confidence that the technique is capturing physiologically important information about chemoreflex effects. First, the respiratory cycle length of periodic breathing at altitude is short (20-25 seconds). Second, the respiratory events have a self-similar duration characteristic - most periodic breathing cycles have a near identical cycle time. Thus, as seen in the right part of the figure, altitude-induced low frequency coupled oscillations have shorter cycle lengths that remain within a restricted frequency range (narrow band coupling, long arrow) relative to normal low frequency coupled sleep oscillations (short arrow). Central apnea, obstructive apnea, periodic breathing and obstructive hypopneas with flow-limitation were all scored using standard criteria within the periods of narrow band coupling.
See this image and copyright information in PMC

Comment on

References

    1. Gay PC. Complex sleep apnea: it really is a disease. J Clin Sleep Med. 2008;4:403–5. - PMC - PubMed
    1. Malhotra A, Bertisch S, Wellman A. Complex sleep apnea: it isn’t really a disease. J Clin Sleep Med. 2008;4:406–8. - PMC - PubMed
    1. Badr MS, Toiber F, Skatrud JB, Dempsey J. Pharyngeal narrowing/occlusion during central sleep apnea. J Appl Physiol. 1995;78:1806–15. - PubMed
    1. Sankri-Tarbichi AG, Rowley JA, Badr MS. Expiratory pharyngeal narrowing during central hypocapnic hypopnea. Am J Respir Crit Care Med. 2009;179:313–9. - PMC - PubMed
    1. Thomas RJ, Tamisier R, Boucher J, et al. Nocturnal hypoxia exposure with simulated altitude for 14 days does not significantly alter working memory or vigilance in humans. Sleep. 2007;30:1195–203. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources