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. 2009 Jun 15;5(3):215-21.

Prevalence of type 2 diabetes in patients with obstructive sleep apnea in a multi-ethnic sample

Kamran Mahmood  1 , Natasha Akhter, Kamal Eldeirawi, Ergün Onal, John W Christman, David W Carley, James J Herdegen
Affiliations

Prevalence of type 2 diabetes in patients with obstructive sleep apnea in a multi-ethnic sample

Kamran Mahmood et al. J Clin Sleep Med. .

Abstract

Study objectives: Relationship of obstructive sleep apnea (OSA) with insulin resistance and type 2 diabetes in Caucasians has been studied, but this association has not been investigated in Hispanic and African-Americans. The objective of this study is to determine the prevalence of type 2 diabetes in patients evaluated for OSA in a predominantly African American and Hispanic sample. The secondary objective is to evaluate the relationship of REM related OSA and type 2 diabetes.

Methods: 1008 consecutive patients who had a comprehensive polysomnography were evaluated. OSA was defined as an obstructive apnea-hypopnea index (AHI) of > or = 5 per hour. REM AHI of > or = 10 was considered to indicate REM related OSA.

Results: The prevalence of type 2 diabetes was 30.1% in the group with OSA compared to 18.6% in those without OSA. The subjects with OSA had significantly increased odds of type 2 diabetes compared with those without OSA (odds ratio = 1.8, 95% confidence interval: 1.3-2.6) but this association became non-significant when controlled for confounding variables and covariates (odds ratio = 1.3, 95% confidence interval: 0.9-2.0). Middle-aged participants with OSA had 2.8 times higher odds for type 2 diabetes, when compared to younger or middle aged without OSA, controlling for covariates. Finally, the odds of type 2 diabetes were 2.0 times higher in patients with REM AHI of > or = 10/h independent of confounding variables.

Conclusions: OSA is not independently associated with type 2 diabetes in a predominantly African American and Hispanic sample. However, the relationship of REM related OSAwith type 2 diabetes may be statistically significant.

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Figures

Figure 1
Figure 1
Adjusted odds ratio for type 2 diabetes in racial subgroups stratified according to presence or absence of obstructive sleep apnea, controlling for BMI, gender, and age.
Figure 2
Figure 2
Adjusted odds ratio for type 2 diabetes mellitus in age subgroups stratified according to presence or absence of obstructive sleep apnea, controlling for BMI, gender and race. *Statistically significant compared to younger subjects without OSA and/or middle aged subjects without OSA. Younger 18-40 years, Middle-aged > 40-60 years, Older > 60 years
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References

    1. American Diabetes Association. Economic costs of diabetes in the US in 2007. Diabetes Care. 2008;31:596–615. - PubMed
    1. Centers for Disease Control and Prevention. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 2005. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2005. Available at: http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2005.pdf.
    1. Meslier N, Gagnadoux F, Giraud P, Person C, Ouksel H, Urban T, Racineux JL. Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur Respir J. 2003;22:156–60. - PubMed
    1. Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE Sleep Heart Health Study Investigators. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol. 2004;160:521–30. - PubMed
    1. Reichmuth KJ, Austin D, Skatrud JB, Young T. Association of sleep apnea and type II diabetes: a population-based study. Am J Respir Crit Care Med. 2005;172:1590–5. - PMC - PubMed

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