Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec;15(12):2049-51.
doi: 10.3201/eid1512.080805.

Identification of Francisella tularensis cluster in central and western Europe

Paola Pilo  1 , Anders Johansson, Joachim Frey
Affiliations

Identification of Francisella tularensis cluster in central and western Europe

Paola Pilo et al. Emerg Infect Dis. 2009 Dec.

Abstract

We conducted a molecular analysis of Francisella tularensis strains isolated in Switzerland and identified a specific subpopulation belonging to a cluster of F. tularensis subsp. holarctica that is widely dispersed in central and western continental Europe. This subpopulation was present before the tularemia epidemics on the Iberian Peninsula.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Genetic relationships between Francisella tularensis subsp. holarctica strains isolated in Switzerland and strains of wider geographic origin. The unweighted pair group method with arithmetic mean phylogram is based on the combined Ftind and multiple-locus variable-number tandem repeat analysis. Bootstrap values >80% are given at the respective nodes and were calculated by using 10,000 iterations. Scale bar indicates genetic distance.
Figure 2
Figure 2
Geographic distribution of Francisella tularensis subsp. holarctica strains of the central and western European genetic cluster isolated in Switzerland. Dots represent the geographic origin of the isolates (from 7 Swiss cantons). The dashed line indicates the Alps. Strains of the subclade B.Br:FTNF002–00 are known to be present in France and Spain.
See this image and copyright information in PMC

References

    1. Avashia SB, Petersen JM, Lindley CM, Schriefer ME, Gage KL, Cetron M, et al. First reported prairie dog–to-human tularemia transmission, Texas, 2002. Emerg Infect Dis. 2004;10:483–6. - PMC - PubMed
    1. Siret V, Barataud D, Prat M, Vaillant V, Ansart S, Le Coustumier A, et al. An outbreak of airborne tularaemia in France, August 2004. Euro Surveill. 2006;11:58–60. - PubMed
    1. Dempsey MP, Dobson M, Zhang C, Zhang M, Lion C, Gutiérrez-Martín CB, et al. Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula. Appl Environ Microbiol. 2007;73:7465–70. 10.1128/AEM.00646-07 - DOI - PMC - PubMed
    1. Kantardjiev T, Ivanov I, Velinov T, Padeshki P, Popov B, Nenova R, et al. Tularemia outbreak, Bulgaria, 1997–2005. Emerg Infect Dis. 2006;12:678–80. - PMC - PubMed
    1. Martin C, Gallardo MT, Mateos L, Vián E, García MJ, Ramos J, et al. Outbreak of tularaemia in Castilla y León, Spain. Euro Surveill. 2007;12:E071108.1. - PubMed

Publication types

LinkOut - more resources