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Review
. 2010 Apr;147(4):469-74.
doi: 10.1016/j.surg.2009.10.026. Epub 2009 Dec 3.

Understanding genetic epidemiologic association studies Part 1: fundamentals

Kaye M Reid-Lombardo  1 , Gloria M Petersen
Affiliations
Review

Understanding genetic epidemiologic association studies Part 1: fundamentals

Kaye M Reid-Lombardo et al. Surgery. 2010 Apr.
No abstract available

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Figures

Figure 1
Figure 1. Components and Structure of DNA
Reproduced by permission: JAMA January 7, 2009, 301(1):74–81. Copyright © 2009 American Medical Association. All rights reserved. The building blocks of DNA are the nucleotides, adenine (A), thymine (T), guanine (G) and cytosine (C). Base pairs are linked to a sugar phosphate backbone in the DNA strand. The nucleotides form base pairs via hydrogen bonds from two strands of DNA to create the DNA helix. The DNA helix is comprised of two single strands of DNA both with a 5’ and 3’ end that bind in opposite directions. The pairing of base pairs are always as follows: adenine binds with thymine, and guanine binds with cytosine. –
Figure 2
Figure 2. Single Nucleotide polymorphism (SNP)
Single Nucleotide polymorphism (SNP), in this example A-T is replaced by G-C, thus creating two potential forms or alleles at this site.
See this image and copyright information in PMC

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References

    1. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860–921. [see comment][erratum appears in Nature 2001 Aug 2;412(6846):565 Note: Szustakowki, J [corrected to Szustakowski, J]] - PubMed
    1. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. The sequence of the human genome. Science. 2001;291:1304–1351. [see comment][erratum appears in Science 2001 Jun 5;292(5523):1838] - PubMed
    1. The International HapMap Consortium. The International HapMap Project. Nature. 2003;426:789–796. - PubMed
    1. The International HapMap Consortium. A haplotype map of the human genome. Nature. 2005;437:1299–1320. - PMC - PubMed
    1. The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007;449:851–861. - PMC - PubMed

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