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Comment
. 2009 Dec 8;16(6):449-50.
doi: 10.1016/j.ccr.2009.11.017.

PI3K regulatory subunits lose control in cancer

Inma Martin Berenjeno  1 , Bart Vanhaesebroeck
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Free article
Comment

PI3K regulatory subunits lose control in cancer

Inma Martin Berenjeno et al. Cancer Cell. .
Free article

Erratum in

  • Cancer Cell. 2010 Feb 17;17(2):213. Martin-Berenjeno, Inma [corrected to Berenjeno, Inma Martin]

Abstract

The PI3K signaling axis is frequently activated in cancer resulting from inactivation of its negative regulator PTEN or activating mutations of the p110alpha catalytic subunit of PI3K. In this issue of Cancer Cell, Jaiswal et al. report that mutations in the p85alpha regulatory subunit of PI3K can also activate this pathway in cancer.

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  • Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.
    Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S. Jaiswal BS, et al. Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016. Cancer Cell. 2009. PMID: 19962665 Free PMC article.

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