Comment
doi: 10.1016/j.ccr.2009.11.014.
Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity
Affiliations
- PMID: 19962661
- PMCID: PMC5513159
- DOI: 10.1016/j.ccr.2009.11.014
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Comment
Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity
Cancer Cell.
.
Abstract
Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.
Comment on
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Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.Cancer Cell. 2009 Dec 8;16(6):475-86. doi: 10.1016/j.ccr.2009.10.023. Cancer Cell. 2009. PMID: 19962666 Free PMC article.
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