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Comment
. 2009 Dec 8;16(6):451-2.
doi: 10.1016/j.ccr.2009.11.014.

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity

Rocio Sotillo  1 , Juan-Manuel Schvartzman, Robert Benezra
Affiliations
Comment

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity

Rocio Sotillo et al. Cancer Cell. .

Abstract

Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.

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