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. 2009:2009:2040-2.
doi: 10.1109/IEMBS.2009.5334439.

Mechanisms of blood pressure reduction by prolonged activation of the baroreflex

Radu Iliescu  1 , Thomas E Lohmeier
Affiliations

Mechanisms of blood pressure reduction by prolonged activation of the baroreflex

Radu Iliescu et al. Annu Int Conf IEEE Eng Med Biol Soc. 2009.

Abstract

Recent technological advances have made the activation of the afferent limb of the baroreflex a viable therapeutic approach for lowering blood pressure. Experimental studies demonstrate sustained reductions in blood pressure in response to electrical baroreflex activation and initial results from clinical trials using device-based therapy for drug-resistant hypertension are promising. Although theoretically obvious at first glance, the mechanisms involved in the blood pressure lowering effect of baroreflex activation elude precise quantification, and experiments designed to investigate them invariably challenge preconceived notions and even dogmas. This paper is a brief overview of our current understanding of these mechanisms.

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References

    1. Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008 Jun;51(6):1403–1419. - PubMed
    1. Schwartz SI, Griffith LS, Neistadt A, Hagfors N. Chronic carotid sinus nerve stimulation in the treatment of essential hypertension. Am J Surg. 1967 Jul;114(1):5–15. - PubMed
    1. Sica DA, Lohmeier TE. Baroreflex activation for the treatment of hypertension: principles and practice. Expert Rev Med Devices. 2006 Sep;3(5):595–601. - PubMed
    1. Lohmeier TE, Barrett AM, Irwin ED. Prolonged activation of the baroreflex: a viable approach for the treatment of hypertension? Curr Hypertens Rep. 2005 Jun;7(3):193–198. - PubMed
    1. Tordoir JH, Scheffers I, Schmidli J, Savolainen H, Liebeskind U, Hansky B, Herold U, Irwin E, Kroon AA, de Leeuw P, Peters TK, Kieval R, Cody R. An implantable carotid sinus baroreflex activating system: surgical technique and short-term outcome from a multi-center feasibility trial for the treatment of resistant hypertension. Eur J Vasc Endovasc Surg. 2007 Apr;33(4):414–421. - PubMed

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