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. 2009 Dec;73(12):2779-82.
doi: 10.1271/bbb.90576. Epub 2009 Dec 7.

Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes

Satoko Akiyama  1 , Shin-ichi Katsumata, Kazuharu Suzuki, Yumi Nakaya, Yoshiko Ishimi, Mariko Uehara
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Free article

Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes

Satoko Akiyama et al. Biosci Biotechnol Biochem. 2009 Dec.
Free article

Abstract

We investigated the hypoglycemic and hypolipidemic effects of two hesperertin glycosides, namely, hesperidin and cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) weanling rats with type 2 diabetes. We demonstrated that hesperidin and CD-hesperetin normalized glucose metabolism by altering the activities of glucose-regulating enzymes and reducing the levels of lipids in the serum and liver of the GK rats. These effects of hesperidin glycosides were partly produced by altering the expression of genes encoding the peroxisome proliferator-activated receptors, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, and the low-density lipoprotein receptor.

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