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Review
. 2009 Dec;106(12):1744-50.

[A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer]

[Article in Japanese]
Masamoto Nakamura  1 , Kasen Kobashikawa, Jiro Tamura, Ryo Takaki, Masaru Ohshiro, Ryoji Matayoshi, Tetsuo Hirata, Fukunori Kinjyo, Jiro Fujita
Affiliations
  • PMID: 19966516
Review

[A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer]

[Article in Japanese]
Masamoto Nakamura et al. Nihon Shokakibyo Gakkai Zasshi. 2009 Dec.

Abstract

A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy. She underwent first cycle of modified FOLFOX6 chemotherapy. She was confused on treatment day 5. Blood test revealed her serum ammonia level to be 121 microg/dl. We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia. Conservative treatment resulted in improvement of metal status. The reason for hyperammonemia after administration of 5FU was the excess production of ammonium from metabolites of 5FU.

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