doi: 10.1016/0163-1047(91)80133-y.
Diazepam impairs place learning in the Morris water maze
Affiliations
- PMID: 1996944
- DOI: 10.1016/0163-1047(91)80133-y
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Diazepam impairs place learning in the Morris water maze
Behav Neural Biol.
1991 Jan.
Abstract
The effect of diazepam (0.3, 1.0, and 3.0 mg/kg) on the acquisition and retention of place learning was evaluated. The analysis of escape latencies indicates that 1.0 and 3.0 mg/kg diazepam significantly impaired the retention of spatial information. When a free swim trial was carried out only control animals showed spatial bias to the target quadrant. The absence of spatial bias in the group that received 0.3 mg/kg suggests that the amnesic effect of diazepam can be seen at doses similar to or even lower than the anxiolytic ones, and that the GABA/benzodiazepine receptor complex is highly sensitive to the cognitive impairment induced by diazepam in spatial tasks.
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