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. 2010 Feb;109(2):e120-5.
doi: 10.1016/j.tripleo.2009.09.022. Epub 2009 Dec 6.

Biological properties of a neutralized 2.5% sodium hypochlorite solution

Virginie Aubut  1 , Ludovic Pommel, Bernard Verhille, Thierry Orsière, Serge Garcia, Imad About, Jean Camps
Affiliations

Biological properties of a neutralized 2.5% sodium hypochlorite solution

Virginie Aubut et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb.

Abstract

Objectives: The objective of this study was to evaluate the influence of neutralizing a 2.5% NaOCl solution on its cytotoxicity, genotoxicity, and tissue-dissolving potential.

Study design: The cytotoxicity and the genotoxicity of Dakin, a 2.5% NaOCl solution, and a neutralized 2.5% NaOCl solution were assessed according to ISO 10993 standards. The weight of palatal mucosa samples placed in neutralized 2.5% NaOCl, 2.5% NaOCl was recorded over time as well as the pH of the solutions.

Results: The neutralized 2.5% NaOCl solution was 10-fold more cytotoxic than the 2.5% NaOCl solution. None of the solutions was genotoxic. The 2.5% NaOCl solution had a better tissue-dissolving capacity than the neutralized 2.5% NaOCl solution. The pH of the 2.5% NaOCl solution and neutralized 2.5% NaOCl solution decreased from 12 to 9 and from 7.5 to 5.6, respectively.

Conclusion: Neutralizing a 2.5% NaOCl solution increased its cytotoxicity, did not induce any genotoxic effect, and reduced its tissue-dissolving ability.

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