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. 1991 Feb;63(2):317-9.
doi: 10.1038/bjc.1991.74.

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

N Scott  1 , P Sagar, J Stewart, G E Blair, M F Dixon, P Quirke
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Free PMC article

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

N Scott et al. Br J Cancer. 1991 Feb.
Free PMC article

Abstract

p53 protein was detected by immunohistochemistry in 42% of 52 colorectal adenocarcinomas. Positive tumours were significantly more frequent in the distal colon, and demonstrated a higher rate of cell proliferation. No correlation was found with tumour grade, Dukes' stage, presence of DNA aneuploidy or patient survival. The role of p53 in colorectal carcinogenesis is discussed with particular reference to differences between proximal and distal large bowel cancers.

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