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Comparative Study
. 1991 Jan;86(3):295-6.
doi: 10.1007/BF00202413.

Consanguinity sans reproche

L P Ten Kate  1 , H Scheffer, M C Cornel, J G van Lookeren Campagne
Affiliations
Comparative Study

Consanguinity sans reproche

L P Ten Kate et al. Hum Genet. 1991 Jan.

Abstract

In a family with two cystic fibrosis (CF) patients and consanguineous parents, DNA analysis showed that the CF in the children was not caused by homozygosity by descent, since two different mutations were involved. A formula is given for calculating the probability that parental consanguinity, if it exists, is causally related to the existence of an autosomal recessive disease in affected children.

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References

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    1. J Med Genet. 1982 Jun;19(3):216-7 - PubMed
    1. J Med Genet. 1977 Feb;14(1):25-9 - PubMed
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