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Clinical Trial
. 1991 Mar;59(3):1206-9.
doi: 10.1128/iai.59.3.1206-1209.1991.

Specific immune response in the human respiratory tract following oral immunization with live typhoid vaccine

B D Forrest  1 , J T LaBrooy, P Robinson, C E Dearlove, D J Shearman
Affiliations
Clinical Trial

Specific immune response in the human respiratory tract following oral immunization with live typhoid vaccine

B D Forrest et al. Infect Immun. 1991 Mar.

Abstract

Specific antibody responses in the lower respiratory tract of human subjects to orally administered Salmonella typhi Ty21a are reported. These responses, predominantly of the immunoglobulin G class, were determined to be a transudate from serum. These results were supported by the similarity in responses to parenteral administration of heat-killed typhoid vaccine. Specific immunoglobulin A antibody was a poor contributor to the respiratory antibody response to either vaccine.

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