Enhanced affinity of opiate receptors for naloxone in striatal slices of morphine-dependent mice
- PMID: 199923
Item in Clipboard
Enhanced affinity of opiate receptors for naloxone in striatal slices of morphine-dependent mice
Res Commun Chem Pathol Pharmacol.
1977 Oct.
Abstract
Slices of corpus striatum were allowed to accumulate 3H-morphine and then they were placed in a small chamber and superfused with Krebs-Ringer bicarbonate solution. 100 to 1 pM of naloxone caused an immediate increase in the release of morphine from the slices when it was placed in the superfusion fluid at 0, 5 or 15 min after the the start of the superfusion. Slices from morphine-dependent mice were more sensitive to the naloxone-induced release of morphine than those of control mice. The data suggest that the affinity of the opiate receptors in the corpus straitum for naloxone is increased in morphine-dependent mice.
Similar articles
-
Further studies on the enhanced affinity of opioid receptors for naloxone in morphine-dependent mice.J Pharmacol Exp Ther. 1979 Jun;209(3):456-61. J Pharmacol Exp Ther. 1979. PMID: 220409 No abstract available.
-
Reduction of opiate binding to brainstem slices associated with the development of tolerance to morphine in rats.J Pharmacol Exp Ther. 1979 Oct;211(1):112-9. J Pharmacol Exp Ther. 1979. PMID: 226669
-
Characteristics of mu and delta opioid binding sites in striatal slices of morphine-tolerant and -dependent mice.Eur J Pharmacol. 1991 Jun 6;198(2-3):157-63. doi: 10.1016/0014-2999(91)90615-w. Eur J Pharmacol. 1991. PMID: 1650700
-
Stereospecific accumulation of dihydromorphine and naltrexone by corpus striatal slices of morphine-dependent mice.Neuropharmacology. 1982 Jan;21(1):57-61. doi: 10.1016/0028-3908(82)90211-8. Neuropharmacology. 1982. PMID: 6278352
-
Morphine-element interactions - The influence of selected chemical elements on neural pathways associated with addiction.J Trace Elem Med Biol. 2020 Jul;60:126495. doi: 10.1016/j.jtemb.2020.126495. Epub 2020 Mar 9. J Trace Elem Med Biol. 2020. PMID: 32179426 Review.
Cited by
-
Sensitivity of morphine-tolerant rats to muscarinic and dopaminergic agonists: relation to tolerance or withdrawal.Psychopharmacology (Berl). 1979 Sep;65(1):27-34. doi: 10.1007/BF00491974. Psychopharmacology (Berl). 1979. PMID: 228336 No abstract available.