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. 1977 Oct;18(2):341-51.

Enhanced affinity of opiate receptors for naloxone in striatal slices of morphine-dependent mice

T Kitano, A E Takemori
  • PMID: 199923

Enhanced affinity of opiate receptors for naloxone in striatal slices of morphine-dependent mice

T Kitano et al. Res Commun Chem Pathol Pharmacol. 1977 Oct.

Abstract

Slices of corpus striatum were allowed to accumulate 3H-morphine and then they were placed in a small chamber and superfused with Krebs-Ringer bicarbonate solution. 100 to 1 pM of naloxone caused an immediate increase in the release of morphine from the slices when it was placed in the superfusion fluid at 0, 5 or 15 min after the the start of the superfusion. Slices from morphine-dependent mice were more sensitive to the naloxone-induced release of morphine than those of control mice. The data suggest that the affinity of the opiate receptors in the corpus straitum for naloxone is increased in morphine-dependent mice.

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