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. 1991 Jan 15;47(1):103-6.
doi: 10.1007/BF02041268.

Gonyauline: a novel endogenous substance shortening the period of the circadian clock of a unicellular alga

T Roenneberg  1 , H Nakamura, L D Cranmer 3rd, K Ryan, Y Kishi, J W Hastings
Affiliations

Gonyauline: a novel endogenous substance shortening the period of the circadian clock of a unicellular alga

T Roenneberg et al. Experientia. .

Abstract

The circadian clock in the unicellular alga Gonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.

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