Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1991 Jan 15;47(1):22-31.
doi: 10.1007/BF02041244.

The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation

J Auwerx  1
Affiliations
Review

The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation

J Auwerx. Experientia. .

Abstract

THP-1 is a human monocytic leukemia cell line. After treatment with phorbol esters, THP-1 cells differentiate into macrophage-like cells which mimic native monocyte-derived macrophages in several respects. Compared to other human myeloid cell lines, such as HL-60, U937, KG-1, or HEL cell lines, differentiated THP-1 cells behave more like native monocyte-derived macrophages. Because of these characteristics, the THP-1 cell line provides a valuable model for studying the mechanisms involved in macrophage differentiation, and for exploring the regulation of macrophage-specific genes as they relate to physiological functions displayed by these cells.

PubMed Disclaimer

References

    1. Cell. 1985 Aug;42(1):23-38 - PubMed
    1. Int J Cancer. 1980 Aug;26(2):171-6 - PubMed
    1. Cell. 1987 Jan 30;48(2):251-60 - PubMed
    1. Cell. 1985 Aug;42(1):203-12 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Feb;86(4):1133-7 - PubMed

Publication types

LinkOut - more resources