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Review
. 2010 Jan:69 Suppl 1:i67-71.
doi: 10.1136/ard.2009.119388.

XBP1: the last two decades

L H Glimcher  1
Affiliations
Review

XBP1: the last two decades

L H Glimcher. Ann Rheum Dis. 2010 Jan.

Abstract

The transcription factor X box-binding protein 1 (XBP1) was isolated two decades ago in a search for regulators of major histocompatibility complex (MHC) class II gene expression. Many years of research finally revealed a protein with many functions, none of them related to the MHC. This paper provided an overview of what this multifunctional transcription factor actually does.

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