Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009 Dec 8;73(23):2037-9.
doi: 10.1212/WNL.0b013e3181c55ee7.

Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome

Peter E Turkeltaub  1 , Miguel A Guzman, Edward B Lee, Steven L Galetta
Affiliations
Case Reports

Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome

Peter E Turkeltaub et al. Neurology. .
No abstract available

PubMed Disclaimer

Figures

None
Figure Histopathology of eosinophilic cellulitis and meningoencephalitis (A, B) Skin biopsy showed a dermal eosinophilic infiltrate associated with necrotic collagen (so-called “flame figures,” shown in inset) consistent with Well syndrome. Stains for microorganisms were negative. (C) Right temporal leptomeningeal and neocortical biopsy revealed a mixed inflammatory infiltrate comprised of lymphocytes, eosinophils (see inset), plasma cells, and macrophages with a prominent perivascular distribution. (D) The inflammatory infiltrate was associated with a florid astrocytic gliosis, highlighted by glial fibrillary acid protein staining (inset). Detailed staining did not reveal evidence for an infectious cause or malignancy. Scale bars: 500 μm (A), 62.5 μm (B, D), 125 μm (C).
See this image and copyright information in PMC

References

    1. Peros-Golubicic TA, Smojver-Jezek SB. Hypereosinophilic syndrome: diagnosis and treatment. Curr Opin Pulmonary Med 2007;13:422–427. - PubMed
    1. Moossavi M, Mehregan DR. Well's syndrome: a clinical and histopathologic review of seven cases. Int J Dermatol 2003;42:62. - PubMed
    1. Gordon MH. Remarks on Hodgkin's disease: a pathogenic agent in the glands, and its application in diagnosis. BMJ 1933;1:641–644. - PMC - PubMed
    1. Durack DT, Sumi SM, Klebanoff SJ. Neurotoxicity of human eosinophils. Proc Natl Acad Sci USA 1979;76:1443–1447. - PMC - PubMed
    1. Durack DT, Ackerman SJ, Loegering DA, Gleich GJ. Purification of human eosinophil-derived neurotoxin. Proc Natl Acad Sci USA 1981;78:5165–5169. - PMC - PubMed

Publication types