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Editorial
. 2009 Dec;94(12):1641-4.
doi: 10.3324/haematol.2009.013961.

The significance of monoclonal gammopathy of undetermined significance

Robert A Kyle, Shaji Kumar
Editorial

The significance of monoclonal gammopathy of undetermined significance

Robert A Kyle et al. Haematologica. 2009 Dec.

Abstract

Since it is now well established that all patients with multiple myeloma have a preceding monoclonal gammopathy of undetermined significance (MGUS), identification of potential risk factors for the progression becomes most important. In this perspective article, Drs. Kyle and Kumar highlight the need for a better understanding of the etiology and biology of MGUS. See related paper on page 1714.

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Figures

Figure 1.
Figure 1.
Survival rate of 241 patients with monoclonal gammopathy of undetermined significance compared with expected survival rate of the USA population using 1930–2000 decennial life tables. Reproduced from Kyle et al.
Figure 2.
Figure 2.
Survival of 1384 patients with monoclonal gammopathy of undetermined significance from South-Eastern Minnesota compared with a normal population (8.1 vs.11.8 years, respectively) ( p <0.001). Reproduced from Kyle et al.
See this image and copyright information in PMC

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References

    1. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003;121:749–57. - PubMed
    1. Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, Offord JR, et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med. 2006;354:1362–9. - PubMed
    1. Kyle RA, Therneau TM, Melton LJ, III, Dispenzieri A, Larson D, Benson J, et al. Monoclonal gammopathy of undetermined significance: estimated incidence and duration prior to recognition. Blood. 2007;110:79a. (Abstract #246)
    1. Cohen HJ, Crawford J, Rao MK, Pieper CF, Currie MS. Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly.[erratum in Am J Med 1998;105:362] Am J Med. 1998;104:439–44. - PubMed
    1. Singh J, Dudley AW, Jr, Kulig KA. Increased incidence of monoclonal gammopathy of undetermined significance in blacks and its age-related differences with whites on the basis of a study of 397 men and one woman in a hospital setting. J Lab Clin Med. 1990;116:785–9. - PubMed

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