Granulocyte transfusion therapy: randomization after all?
- PMID: 19996116
- PMCID: PMC2791939
- DOI: 10.3324/haematol.2009.013680
Granulocyte transfusion therapy: randomization after all?
Abstract
Granulocyte transfusions were first used to treat infections in neutropenic patients in the early 1960s. The first donors were patients with chronic myeloid leukemia. Forty years later the value of these transfusions remains unclear. In this perspective article Drs. Drewniak and Kuijpers discuss the relevant data. See related paper on page 1661.
Comment on
-
Granulocyte transfusions in severe aplastic anemia: an eleven-year experience.Haematologica. 2009 Dec;94(12):1661-8. doi: 10.3324/haematol.2009.010231. Haematologica. 2009. PMID: 19996117 Free PMC article.
Similar articles
-
Granulocyte transfusions in severe aplastic anemia: an eleven-year experience.Haematologica. 2009 Dec;94(12):1661-8. doi: 10.3324/haematol.2009.010231. Haematologica. 2009. PMID: 19996117 Free PMC article.
-
Numerous granulocyte transfusions to a patient with severe aplastic anemia without severe complication.Transfus Apher Sci. 2013 Jun;48(3):371-3. doi: 10.1016/j.transci.2013.04.019. Epub 2013 Apr 18. Transfus Apher Sci. 2013. PMID: 23602057
-
Safety and efficacy of therapeutic early onset granulocyte transfusions in pediatric patients with neutropenia and severe infections.Transfusion. 2006 Nov;46(11):1909-14. doi: 10.1111/j.1537-2995.2006.00996.x. Transfusion. 2006. PMID: 17076845 Clinical Trial.
-
Granulocyte transfusions: A concise review for practitioners.Cytotherapy. 2017 Nov;19(11):1256-1269. doi: 10.1016/j.jcyt.2017.08.012. Epub 2017 Sep 12. Cytotherapy. 2017. PMID: 28916227 Free PMC article. Review.
-
Granulocyte transfusions in the management of invasive fungal infections.Br J Haematol. 2017 May;177(3):357-374. doi: 10.1111/bjh.14597. Epub 2017 Mar 14. Br J Haematol. 2017. PMID: 28295178 Free PMC article. Review.
Cited by
-
Development of autologous blood cell therapies.Exp Hematol. 2016 Oct;44(10):887-94. doi: 10.1016/j.exphem.2016.06.005. Epub 2016 Jun 21. Exp Hematol. 2016. PMID: 27345108 Free PMC article. Review.
-
Role of granulocyte transfusions in combating life-threatening infections in patients with severe neutropenia: Experience from a tertiary care centre in North India.PLoS One. 2018 Dec 27;13(12):e0209832. doi: 10.1371/journal.pone.0209832. eCollection 2018. PLoS One. 2018. PMID: 30589898 Free PMC article.
-
Membrane permeability of the human granulocyte to water, dimethyl sulfoxide, glycerol, propylene glycol and ethylene glycol.Cryobiology. 2014 Feb;68(1):35-42. doi: 10.1016/j.cryobiol.2013.11.004. Epub 2013 Nov 20. Cryobiology. 2014. PMID: 24269528 Free PMC article.
-
Infections Caused by Acinetobacter baumannii in Recipients of Hematopoietic Stem Cell Transplantation.Front Oncol. 2014 Jul 14;4:186. doi: 10.3389/fonc.2014.00186. eCollection 2014. Front Oncol. 2014. PMID: 25072028 Free PMC article. Review.
-
Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components.Haematologica. 2016 May;101(5):587-96. doi: 10.3324/haematol.2015.136630. Epub 2016 Jan 22. Haematologica. 2016. PMID: 26802050 Free PMC article.
References
-
- Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med. 1966;64:328–40. - PubMed
-
- Gerson SL, Talbot GH, Hurwitz S, Storm BL, Lusk EJ, Cassileth PA. Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med. 1984;100:345–51. - PubMed
-
- Freireich EJ, Levin RH, Whang J, Carbone PP, Bronson W, Morse EE. The function and the fate of transfused leukocytes from donors with chronic myelocytic leukemia in leukopenic patients. Ann NY Acad Sci. 1964;113:1081–9. - PubMed
-
- Herzig RH, Herzig GP, Graw RG, Jr, Bull MI, Ray KK. Successful granulocyte transfusion therapy for Gram-negative septicemia. A prospectively randomized controlled study. N Engl J Med. 1977;296:701–5. - PubMed
-
- Graw RG, Jr, Herzig G, Perry S, Henderson ES. Normal granulocyte transfusion therapy: treatment of septicemia due to Gram-negative bacteria. N Engl J Med. 1972;287:367–71. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources