Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Nov-Dec;50(6):570-9.
doi: 10.1176/appi.psy.50.6.570.

Depression and diabetes: factors associated with major depression at five-year follow-up

Wayne Katon  1 , Joan Russo, Elizabeth H B Lin, Susan R Heckbert, Paul Ciechanowski, Evette J Ludman, Michael Von Korff
Affiliations

Depression and diabetes: factors associated with major depression at five-year follow-up

Wayne Katon et al. Psychosomatics. 2009 Nov-Dec.

Abstract

Background: In patients with diabetes, comorbid depression has been shown to be associated with increased medical symptom burden, additional functional impairment, poor self-care, increased risk of macrovascular and microvascular complications, higher medical costs, and greater mortality.

Objective: The authors performed a longitudinal observation to assess the pathway between diabetes complications and subsequent depression.

Method: In a prospective study of primary-care patients with diabetes (N=2,759), the authors determined, from automated data and chart review, whether macrovascular or microvascular events or coronary, cerebrovascular, or peripheral vascular procedures during follow-up were associated with meeting criteria for major depression at 5-year follow-up.

Results: After controlling for baseline severity of depression symptoms and history of depression, having one-or-more coronary procedures during follow-up, and baseline severity of diabetes symptoms were strong predictors of having major depression at 5-year follow-up.

Conclusion: The risk of major depression among persons with diabetes is increased by previous depression history, baseline diabetes symptoms, and having had cardiovascular procedures.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pathways-Follow-up Study Flow Diagram
Figure 2
Figure 2
Relationship* between Number of Depression Symptoms at Baseline and Major Depression at 5 Year Follow-Up
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Katon WJ. Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biol Psychiatry. 2003;54:216–26. - PubMed
    1. Ludman EJ, Katon W, Russo J, et al. Depression and diabetes symptom burden. Gen Hosp Psychiatry. 2004;26:430–6. - PubMed
    1. Von Korff M, Katon W, Lin EH, et al. Work disability among individuals with diabetes. Diabetes Care. 2005;28:1326–32. - PubMed
    1. Von Korff M, Katon W, Lin EH, et al. Potentially modifiable factors associated with disability among people with diabetes. Psychosom Med. 2005;67:233–40. - PubMed
    1. Lin EH, Katon W, Von Korff M, et al. Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care. 2004;27:2154–60. - PubMed

Publication types

MeSH terms