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. 2009 Nov-Dec;50(6):570-9.
doi: 10.1176/appi.psy.50.6.570.

Depression and diabetes: factors associated with major depression at five-year follow-up

Wayne Katon  1 , Joan Russo, Elizabeth H B Lin, Susan R Heckbert, Paul Ciechanowski, Evette J Ludman, Michael Von Korff
Affiliations

Depression and diabetes: factors associated with major depression at five-year follow-up

Wayne Katon et al. Psychosomatics. 2009 Nov-Dec.

Abstract

Background: In patients with diabetes, comorbid depression has been shown to be associated with increased medical symptom burden, additional functional impairment, poor self-care, increased risk of macrovascular and microvascular complications, higher medical costs, and greater mortality.

Objective: The authors performed a longitudinal observation to assess the pathway between diabetes complications and subsequent depression.

Method: In a prospective study of primary-care patients with diabetes (N=2,759), the authors determined, from automated data and chart review, whether macrovascular or microvascular events or coronary, cerebrovascular, or peripheral vascular procedures during follow-up were associated with meeting criteria for major depression at 5-year follow-up.

Results: After controlling for baseline severity of depression symptoms and history of depression, having one-or-more coronary procedures during follow-up, and baseline severity of diabetes symptoms were strong predictors of having major depression at 5-year follow-up.

Conclusion: The risk of major depression among persons with diabetes is increased by previous depression history, baseline diabetes symptoms, and having had cardiovascular procedures.

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Figures

Figure 1
Figure 1
Pathways-Follow-up Study Flow Diagram
Figure 2
Figure 2
Relationship* between Number of Depression Symptoms at Baseline and Major Depression at 5 Year Follow-Up
See this image and copyright information in PMC

References

    1. Katon WJ. Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biol Psychiatry. 2003;54:216–26. - PubMed
    1. Ludman EJ, Katon W, Russo J, et al. Depression and diabetes symptom burden. Gen Hosp Psychiatry. 2004;26:430–6. - PubMed
    1. Von Korff M, Katon W, Lin EH, et al. Work disability among individuals with diabetes. Diabetes Care. 2005;28:1326–32. - PubMed
    1. Von Korff M, Katon W, Lin EH, et al. Potentially modifiable factors associated with disability among people with diabetes. Psychosom Med. 2005;67:233–40. - PubMed
    1. Lin EH, Katon W, Von Korff M, et al. Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care. 2004;27:2154–60. - PubMed

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