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. 2009 Dec 14;15(46):5770-5.
doi: 10.3748/wjg.15.5770.

Confocal laser endomicroscopy in the "in vivo" histological diagnosis of the gastrointestinal tract

Giovanni D De Palma  1
Affiliations

Confocal laser endomicroscopy in the "in vivo" histological diagnosis of the gastrointestinal tract

Giovanni D De Palma. World J Gastroenterol. .

Abstract

Recent technological advances in miniaturization have allowed for a confocal scanning microscope to be integrated into a conventional flexible endoscope, or into trans-endoscopic probes, a technique now known as confocal endomicroscopy or confocal laser endomicroscopy. This newly-developed technology has enabled endoscopists to collect real-time in vivo histological images or "virtual biopsies" of the gastrointestinal mucosa during endoscopy, and has stimulated significant interest in the application of this technique in clinical gastroenterology. This review aims to evaluate the current data on the technical aspects and the utility of this new technology in clinical gastroenterology and its potential impact in the future, particularly in the screening or surveillance of gastrointestinal neoplasia.

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Figures

Figure 1
Figure 1
Schematic of confocal endomicroscopy principles.
Figure 2
Figure 2
The endoscope-based confocal laser endomicroscopy (eCLE) imaging system: the distal tip.
Figure 3
Figure 3
The probe-based CLE (pCLE) imaging system.
Figure 4
Figure 4
pCLE fluorescein sodium 10% imaging of the normal colon (A) and normal duodenum (B).
Figure 5
Figure 5
pCLE fluorescein sodium 10% imaging of an adenomatous colonic polyp (A) and colonic adenocarcinoma (B).
See this image and copyright information in PMC

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