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Randomized Controlled Trial
. 2009 Dec 14;15(46):5851-4.
doi: 10.3748/wjg.15.5851.

Effect of implanting fibrin sealant with ropivacaine on pain after laparoscopic cholecystectomy

Jian-Zhu Fu  1 , Jie Li, Ze-Li Yu
Affiliations
Randomized Controlled Trial

Effect of implanting fibrin sealant with ropivacaine on pain after laparoscopic cholecystectomy

Jian-Zhu Fu et al. World J Gastroenterol. .

Abstract

Aim: To investigate the safety and efficacy of implanting fibrin sealant with sustained-release ropivacaine in the gallbladder bed for pain after laparoscopic cholecystectomy (LC).

Methods: Sixty patients (American Society of Anesthesiologists physical status was I or II and underwent LC) were randomly divided into three equal groups: group A (implantation of fibrin sealant in the gallbladder bed), group B (implantation of fibrin sealant carrying ropivacaine in the gallbladder bed), and group C (normal saline in the gallbladder bed). Postoperative pain was evaluated, and pain relief was assessed by visual analog scale (VAS) scoring.

Results: The findings showed that 81.7% of patients had visceral pain, 50% experienced parietal, and 26.7% reported shoulder pain after LC. Visceral pain was significantly less in group B patients than in the other groups (P < 0.05), and only one patient in this group experienced shoulder pain. The mean VAS score in group B patients was lower than that in the other groups.

Conclusion: Visceral pain is prominent after LC and can be effectively controlled by implanting fibrin sealant combined with ropivacaine in the gallbladder bed.

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