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Case Reports
. 2009 Dec 14;15(46):5882-3.
doi: 10.3748/wjg.15.5882.

Lethal neuroendocrine carcinoma in ulcerative colitis

Hugh J Freeman, Ken Berean
Case Reports

Lethal neuroendocrine carcinoma in ulcerative colitis

Hugh J Freeman et al. World J Gastroenterol. .

Abstract

A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine carcinoma. Prior biopsies obtained from multiple sites in the colon during endoscopic surveillance were reported to show only inflammatory changes without dysplasia. Although operator-dependent, repeated endoscopic studies may have limitations during surveillance programs because the biological behavior of some colonic neoplastic lesions may have a rapid and very aggressive clinical course.

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References

    1. Grassia R, Bodini P, Dizioli P, Staiano T, Iiritano E, Bianchi G, Buffoli F. Neuroendocrine carcinomas arising in ulcerative colitis: coincidences or possible correlations? World J Gastroenterol. 2009;15:4193–4195. - PMC - PubMed
    1. Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, et al. Neuroendocrine carcinomas of the colon and rectum. Dis Colon Rectum. 2004;47:163–169. - PubMed
    1. Chetty R. Requiem for the term 'carcinoid tumour' in the gastrointestinal tract? Can J Gastroenterol. 2008;22:357–358. - PMC - PubMed
    1. Greenstein AJ, Balasubramanian S, Harpaz N, Rizwan M, Sachar DB. Carcinoid tumor and inflammatory bowel disease: a study of eleven cases and review of the literature. Am J Gastroenterol. 1997;92:682–685. - PubMed
    1. Freeman HJ. Appendiceal carcinoids in Crohn's disease. Can J Gastroenterol. 2003;17:43–46. - PubMed