doi: 10.1016/0005-2795(73)90252-3.
Demonstration of three anomalous plasma proteins induced by a vitamin K antagonist
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- PMID: 19999738
- DOI: 10.1016/0005-2795(73)90252-3
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Demonstration of three anomalous plasma proteins induced by a vitamin K antagonist
Biochim Biophys Acta.
.
Abstract
With the aid of precipitating antibodies against the bovine coagulation factors II, IX, and X three immunologically non-identical proteins can be demonstrated that are induced by the administration of a vitamin K antagonist (phenprocoumon). Each of these proteins is immunologically identical to one of three coagulation factors mentioned. The proteins differ from normal coagulation factors (a) by a lack of biological activity; (b) by a faster anodic migration rate in the presence of Ca2+. The proteins appear in the plasma concomitantly with the decrease of the normal factor.
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