Treatment outcome in children with tuberculosis in southern Ethiopia
- PMID: 20001277
- DOI: 10.1080/00365540902865736
Treatment outcome in children with tuberculosis in southern Ethiopia
Abstract
Our study took place at 8 tuberculosis diagnostic and treatment centres in Sidama Zone, southern Ethiopia. Our objectives were to assess the status of TB treatment in children and risk factors associated with unfavourable outcome. A retrospective study was based on information retained in TB registers of the centres. Demographic characteristics and treatment outcome of children registered between 2002 and 2007 were retrieved. Risk factors for unfavourable outcome (failure, default or death) were calculated. Of 851 (165 with smear-positive, 475 smear-negative and 206 extrapulmonary TB) children, 655 (77%) were cured or completed and 124 (14.6%) had unfavourable outcome. Treatment success rate increased with age from 66% in children <5 y old to 81% in 5-9-y-olds and 85% in >/=10-y-olds (p <0.001). 75% of patients with smear-negative TB had favourable outcome compared to 80.6% for smear-positive cases (p =0.06). Age <5 y, lack of smear conversion in the second month and living in rural areas were independent risk factors for unfavourable treatment outcome. In conclusion, the outcome of TB treatment varies with age, residency and smear results. Reporting only cases with smear-positive TB disproportionally excludes a higher proportion of children than adults. Surveillance systems to monitor TB outcome in children need to be improved.
Similar articles
-
Factors associated with poor tuberculosis treatment outcome in the Southern Region of Ethiopia.Int J Tuberc Lung Dis. 2010 Aug;14(8):973-9. Int J Tuberc Lung Dis. 2010. PMID: 20626941
-
Childhood tuberculosis in Malawi: nationwide case-finding and treatment outcomes.Int J Tuberc Lung Dis. 2002 May;6(5):424-31. Int J Tuberc Lung Dis. 2002. PMID: 12019918
-
Clinical aspects and treatment outcome in HIV-associated pulmonary tuberculosis: an experience from a Thai referral centre.J Med Assoc Thai. 1994 Oct;77(10):520-5. J Med Assoc Thai. 1994. PMID: 7745373
-
Treatment Outcome of Tuberculosis Patients under Directly Observed Treatment Short Course and Factors Affecting Outcome in Southern Ethiopia: A Five-Year Retrospective Study.PLoS One. 2016 Feb 26;11(2):e0150560. doi: 10.1371/journal.pone.0150560. eCollection 2016. PLoS One. 2016. PMID: 26918458 Free PMC article.
-
Pediatric TB: issues related to current and future treatment options.Future Microbiol. 2009 Aug;4(6):661-75. doi: 10.2217/fmb.09.39. Future Microbiol. 2009. PMID: 19659423 Review.
Cited by
-
Comparing tuberculosis in children aged under 5 versus 5 to 14 years old in a rural hospital in southern Ethiopia: an 18-year retrospective cross-sectional study.BMC Public Health. 2019 Jul 2;19(1):856. doi: 10.1186/s12889-019-7206-2. BMC Public Health. 2019. PMID: 31266471 Free PMC article.
-
Xpert MTB/RIF on Stool Is Useful for the Rapid Diagnosis of Tuberculosis in Young Children With Severe Pulmonary Disease.Pediatr Infect Dis J. 2017 Sep;36(9):837-843. doi: 10.1097/INF.0000000000001563. Pediatr Infect Dis J. 2017. PMID: 28151842 Free PMC article.
-
Predictors of pediatric tuberculosis in public health facilities of Bale zone, Oromia region, Ethiopia: a case control study.BMC Infect Dis. 2018 Jun 4;18(1):252. doi: 10.1186/s12879-018-3163-0. BMC Infect Dis. 2018. PMID: 29866076 Free PMC article.
-
The Diagnostic Accuracy of Chest Radiographic Features for Pediatric Intrathoracic Tuberculosis.Clin Infect Dis. 2022 Sep 29;75(6):1014-1021. doi: 10.1093/cid/ciac011. Clin Infect Dis. 2022. PMID: 35015857 Free PMC article.
-
Childhood tuberculosis and its treatment outcomes in Addis Ababa: a 5-years retrospective study.BMC Pediatr. 2014 Mar 3;14:61. doi: 10.1186/1471-2431-14-61. BMC Pediatr. 2014. PMID: 24581267 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical