Obesity treatment: novel peripheral targets
- PMID: 20002077
- PMCID: PMC2810794
- DOI: 10.1111/j.1365-2125.2009.03522.x
Obesity treatment: novel peripheral targets
Abstract
Our knowledge of the complex mechanisms underlying energy homeostasis has expanded enormously in recent years. Food intake and body weight are tightly regulated by the hypothalamus, brainstem and reward circuits, on the basis both of cognitive inputs and of diverse humoral and neuronal signals of nutritional status. Several gut hormones, including cholecystokinin, glucagon-like peptide-1, peptide YY, oxyntomodulin, amylin, pancreatic polypeptide and ghrelin, have been shown to play an important role in regulating short-term food intake. These hormones therefore represent potential targets in the development of novel anti-obesity drugs. This review focuses on the role of gut hormones in short- and long-term regulation of food intake, and on the current state of development of gut hormone-based obesity therapies.
References
-
- WHO Global Infobase team. The suRF Report 2. Surveillance of Chronic Disease Risk Factors: Country-Level Data and Comparable Estimates. Geneva: World Health Organisation; 2007.
-
- Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999–2000. JAMA. 2002;288:1723–7. - PubMed
-
- de Looper M, Bhatia K. Australian Health Trends 2001. Canberra: Australian Institute of Health and Welfare; 2001. AIHW Cat. No. PHE 24.
-
- National Audit Office. Tackling obesity in England. London: The Stationery Office; 2001. Report by the Comptroller and Auditor General.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical