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. 2009 Dec;55(6):660-4.
doi: 10.1111/j.1365-2559.2009.03431.x.

Intravascular lymphocytosis in acute appendicitis: potential mimicry of chronic lymphocytic leukaemia

Sandra Lee  1 , Robert T Ogilvie, Marc Dupre, Zu-Hua Gao
Affiliations

Intravascular lymphocytosis in acute appendicitis: potential mimicry of chronic lymphocytic leukaemia

Sandra Lee et al. Histopathology. 2009 Dec.

Abstract

Aims: Intravascular lymphocytosis (IVL) in appendectomy specimens is a fairly common phenomenon but has not been described and studied in detail. The aim was to describe the IVL phenomenon in appendiceal specimens removed for appendicitis that can mimic chronic lymphocytic leukaemia and to investigate factors that could contribute to the development of IVL.

Methods and results: The clinicopathology of 100 appendectomy cases and the appendices from 20 right hemicolectomy cases were reviewed. The IVL phenomenon was more commonly seen in laparoscopic appendectomy specimens [Fisher's exact 0.011, odds ratio (OR) 3.14] and in patients <38 years old (Fisher's exact 0.012, OR 3.01).

Conclusions: Surgical manipulation and the patient's innate immunity are contributary factors to the development of the IVL phenomenon. Pathologists should be aware of this histological artefact in order to prevent overdiagnosis of intravascular lymphoid neoplasia.

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