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Review
. 2009 Dec 15:7:106.
doi: 10.1186/1479-5876-7-106.

Circulating endothelial progenitor cells: a new approach to anti-aging medicine?

Nina A Mikirova  1 , James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle W H Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Doru T Alexandrescu, Thomas E Ichim, Neil H Riordan
Affiliations
Review

Circulating endothelial progenitor cells: a new approach to anti-aging medicine?

Nina A Mikirova et al. J Transl Med. .

Abstract

Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a potent means of preventing/treating some of the most fearful aspects of aging such as loss of mental, cardiovascular, and sexual function.Endothelial precursor cells (EPC) provide a continual source of replenishment for damaged or senescent blood vessels. In this review we discuss the biological relevance of circulating EPC in a variety of pathologies in order to build the case that these cells act as an endogenous mechanism of regeneration. Factors controlling EPC mobilization, migration, and function, as well as therapeutic interventions based on mobilization of EPC will be reviewed. We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects.

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Figures

Figure 1
Figure 1
Stem-Kine Supplementation Augments Circulating EPC. StemKine was administered at a concentration of 2,800 mg/day to 6 healthy volunteers. Flow cytometric analysis of cells double-staining for VEGFR2 and CD34 was performed with samples extracted at the indicated timepoints. Y-axis represents percentage double positive cells from cells.
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References

    1. Herrmann J, Lerman A. The Endothelium - the Cardiovascular Health Barometer. Herz. 2008;33:343–353. doi: 10.1007/s00059-008-3088-2. - DOI - PubMed
    1. Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. J Appl Physiol. 2006;100:1059–1064. doi: 10.1152/japplphysiol.00954.2005. - DOI - PubMed
    1. Saenz de Tejada I, Angulo J, Cellek S, Gonzalez-Cadavid N, Heaton J, Pickard R, Simonsen U. Pathophysiology of erectile dysfunction. J Sex Med. 2005;2:26–39. doi: 10.1111/j.1743-6109.2005.20103.x. - DOI - PubMed
    1. Provis JM, Penfold PL, Cornish EE, Sandercoe TM, Madigan MC. Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration. Clin Exp Optom. 2005;88:269–281. - PubMed
    1. Izikki M, Fadel E, Humbert M, Tu L, Zadigue P, Dartevelle P, Simonneau G, Adnot S, Maitre B, Raffestin B, Eddahibi S. Role for dysregulated endothelium- derived FGF2 signaling in progression of pulmonary hypertension. Rev Mal Respir. 2008;25:1192.

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