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Randomized Controlled Trial
. 2010 Feb 10;28(6):1558-65.
doi: 10.1016/j.vaccine.2009.11.055. Epub 2009 Dec 8.

Impact of influenza-like illness and effectiveness of influenza vaccination in oncohematological children who have completed cancer therapy

Susanna Esposito  1 , Valerio Cecinati, Barbara Scicchitano, Giovanni Carlo Delvecchio, Nicola Santoro, Doriana Amato, Claudio Pelucchi, Momcilo Jankovic, Domenico De Mattia, Nicola Principi
Affiliations
Randomized Controlled Trial

Impact of influenza-like illness and effectiveness of influenza vaccination in oncohematological children who have completed cancer therapy

Susanna Esposito et al. Vaccine. .

Abstract

In order to evaluate the impact of influenza-like illness and the effectiveness of influenza vaccination in children with oncohematological disease who have completed cancer therapy, 182 children with a diagnosis of oncohematological disease were divided into two subgroups on the basis of the length of time off therapy (<6 months or 6-24 months) and randomised 1:1 to receive influenza vaccination or not. The controls were 91 otherwise healthy children unvaccinated against influenza. The results show that the clinical and socioeconomic impact of influenza-like illnesses and the effectiveness of influenza vaccination in oncohematological children who have completed cancer therapy are related to the length of the off therapy period, and seem to be significantly greater in those who have been off therapy for less than 6 months in comparison with healthy controls. This suggests that the administration of influenza vaccination should be strongly recommended only among oncohematological children who have been off therapy for less than 6 months.

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Figures

Fig. 1
Fig. 1
Diagram showing the whole study population and how it has been divided into the different arms of the study.
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