Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec 9;17(12):1547-1548.
doi: 10.1016/j.str.2009.11.003.

Expanding the ribosomal universe

Jonathan D Dinman  1 , Terri Goss Kinzy  2
Affiliations

Expanding the ribosomal universe

Jonathan D Dinman et al. Structure. .

Abstract

In this issue of Structure, Taylor et al. (2009) present the most complete model of an eukaryotic ribosome to date. This achievement represents a critical milestone along the path to structurally defining the unique aspects of the eukaryotic protein synthetic machinery.

PubMed Disclaimer

Figures

Figure 1
Figure 1. The eukaryotic ribosome over 40 years
The pioneering work of Palade and co workers demonstrated ribonucleic particles from eukaryotes (Kirsch et al., 1960), rats), which has evolved (insert) into molecular level understanding of the ribosome (Taylor et al., 2009) showing the 80S density map (mesh) and fitted atomic structure, reproduced from (Frank, 2009). Structure in front, in red, is eEF2. Courtesy Lila Rubenstein and Joachim Frank.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Ban N, Nissen P, Hansen J, Moore PB, Steitz TA. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science. 2000;289:905–920. - PubMed
    1. Brodersen DE, Carter AP, Clemons WM, Jr, Morgan-Warren RJ, Murphy FV, Ogle JM, Tarry MJ, Wimberly BT, Ramakrishnan V. Atomic structures of the 30S subunit and its complexes with ligands and antibiotics. Cold Spring Harb.Symp.Quant.Biol. 2001;66:17–32. - PubMed
    1. Dinman JD. The eukaryotic ribosome: current status and challenges. J.Biol.Chem. 2009;284:11761–11765. - PMC - PubMed
    1. Frank J. Single-particle reconstrution of biological macromolecules in electron microscopy - 30 years. Quarterly Reviews of Biophysics. 2009 (in press) - PMC - PubMed
    1. Gregory LA, Aguissa-Toure AH, Pinaud N, Legrand P, Gleizes PE, Fribourg S. Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19. Nucleic Acids Res. 2007;35:5913–5921. - PMC - PubMed

LinkOut - more resources