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Comment

. 2009 Dec;85(6):942-5.

doi: 10.1016/j.ajhg.2009.11.006.

Response to Falush: a role for cis-element polymorphisms in HD

Simon C Warby, Henk Visscher, Stefanie Butland, Christopher E Pearson, Michael R Hayden

PMID: 20004773
PMCID: PMC2790565
DOI: 10.1016/j.ajhg.2009.11.006

Comment

Response to Falush: a role for cis-element polymorphisms in HD

Simon C Warby et al. Am J Hum Genet. 2009 Dec.

. 2009 Dec;85(6):942-5.

doi: 10.1016/j.ajhg.2009.11.006.

Authors

Simon C Warby, Henk Visscher, Stefanie Butland, Christopher E Pearson, Michael R Hayden

PMID: 20004773
PMCID: PMC2790565
DOI: 10.1016/j.ajhg.2009.11.006

No abstract available

PubMed Disclaimer

Comment on

Haplotype background, repeat length evolution, and Huntington's disease.
Falush D. Falush D. Am J Hum Genet. 2009 Dec;85(6):939-42. doi: 10.1016/j.ajhg.2009.11.002. Am J Hum Genet. 2009. PMID: 20004772 Free PMC article. No abstract available.

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References

1. Warby S.C., Montpetit A., Hayden A.R., Carroll J.B., Butland S.L., Visscher H., Collins J.A., Semaka A., Hudson T.J., Hayden M.R. CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup. Am. J. Hum. Genet. 2009;84:351–366. - PMC - PubMed
1. Leeflang E.P., Tavaré S., Marjoram P., Neal C.O., Srinidhi J., MacFarlane H., MacDonald M.E., Gusella J.F., de Young M., Wexler N.S., Arnheim N. Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism. Hum. Mol. Genet. 1999;8:173–183. - PubMed
1. Pollard L.M., Sharma R., Gómez M., Shah S., Delatycki M.B., Pianese L., Monticelli A., Keats B.J., Bidichandani S.I. Replication-mediated instability of the GAA triplet repeat mutation in Friedreich ataxia. Nucleic Acids Res. 2004;32:5962–5971. - PMC - PubMed
1. Cleary J.D., Nichol K., Wang Y.H., Pearson C.E. Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells. Nat. Genet. 2002;31:37–46. - PubMed
1. Langbehn D.R., Hayden M.R., Paulsen J.S., and the PREDICT-HD Investigators of the Huntington Study Group CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2009 Published online June 22, 2009. - PMC - PubMed

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