Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jun;41(2):145-9.
doi: 10.1016/j.jbtep.2009.11.007. Epub 2009 Dec 1.

Sleep, illness course, and concurrent symptoms in inter-episode bipolar disorder

Polina Eidelman  1 , Lisa S Talbot, June Gruber, Allison G Harvey
Affiliations

Sleep, illness course, and concurrent symptoms in inter-episode bipolar disorder

Polina Eidelman et al. J Behav Ther Exp Psychiatry. 2010 Jun.

Abstract

We investigated associations between sleep, illness course, and concurrent symptoms in 21 participants with bipolar disorder who were inter-episode. Sleep was assessed using a week-long diary. Illness course and symptoms were assessed via validated semi-structured interviews. Lower and more variable sleep efficiency and more variable total wake time were associated with more lifetime depressive episodes. Variability in falling asleep time was positively correlated with concurrent depressive symptoms. Sleep efficiency was positively correlated with concurrent manic symptoms. These findings suggest that inter-episode sleep disturbance is associated with illness course and that sleep may be an important intervention target in bipolar disorder.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Dr. Harvey is a consultant to Actelion Pharmaceuticals and a speaker for Sanofiaventis and the Sleep Medicine Education Institute. All other authors declare that they have no conflicts of interest. Funding for this study was provided by NARSAD (AGH).

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Borbély AA, Achermann P. Sleep homeostasis and models of sleep regulation. In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. Philadelphia: Elsevier Saunders; 2005. pp. 405–417.
    1. Buysse DJ, Ancoli-Israel S, Edinger JD, Lichstein KL, Morin CM. Recommendations for a standard research assessment of insomnia. Sleep. 2006;29:1155–1173. - PubMed
    1. Denicoff KD, Smith-Jackson EE, Disney ER, et al. Comparative prophylactic efficacy of lithium, carbamazepine, and the combination in bipolar disorder. Journal of Clinical Psychiatry. 1997;58:470–478. - PubMed
    1. Dijk DJ, Cajochen C. Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. J Biol Rhythms. 1997;12:627–635. - PubMed
    1. First MB, Spitzer RL, Gibbon M, Williams JBW. Biometrics Research Department, New York State. New York: Psychiatric Institute; 1994. Structured Clinical Interview for DSM-IV- Patient Version 1994.

Publication types