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. 2010 Jun;41(2):145-9.
doi: 10.1016/j.jbtep.2009.11.007. Epub 2009 Dec 1.

Sleep, illness course, and concurrent symptoms in inter-episode bipolar disorder

Polina Eidelman  1 , Lisa S Talbot, June Gruber, Allison G Harvey
Affiliations

Sleep, illness course, and concurrent symptoms in inter-episode bipolar disorder

Polina Eidelman et al. J Behav Ther Exp Psychiatry. 2010 Jun.

Abstract

We investigated associations between sleep, illness course, and concurrent symptoms in 21 participants with bipolar disorder who were inter-episode. Sleep was assessed using a week-long diary. Illness course and symptoms were assessed via validated semi-structured interviews. Lower and more variable sleep efficiency and more variable total wake time were associated with more lifetime depressive episodes. Variability in falling asleep time was positively correlated with concurrent depressive symptoms. Sleep efficiency was positively correlated with concurrent manic symptoms. These findings suggest that inter-episode sleep disturbance is associated with illness course and that sleep may be an important intervention target in bipolar disorder.

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Conflict of interest statement

Disclosure: Dr. Harvey is a consultant to Actelion Pharmaceuticals and a speaker for Sanofiaventis and the Sleep Medicine Education Institute. All other authors declare that they have no conflicts of interest. Funding for this study was provided by NARSAD (AGH).

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