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. 1991;20(1):31-6.
doi: 10.1007/BF00243718.

Magnetic resonance imaging reflects cartilage proteoglycan degradation in the rabbit knee

P K Paul  1 , E O'Byrne, V Blancuzzi, D Wilson, D Gunson, F L Douglas, J Z Wang, R S Mezrich
Affiliations

Magnetic resonance imaging reflects cartilage proteoglycan degradation in the rabbit knee

P K Paul et al. Skeletal Radiol. 1991.

Abstract

Cartilage degeneration in osteoarthritis is initiated by a loss of proteoglycan. Intra-articular injection of papain causes a reversible loss of proteoglycan in rabbit knees. Rabbits were scanned with magnetic resonance imaging (MRI), using a 1.5T Signa superconducting magnet with 3 inch surface coil. Spin echo sequences were performed in the coronal and sagittal planes at 0, 24, 48, and 72 h after intra-articular injection of papain to obtain T1, proton density, and T2-weighted images. Cartilage proteoglycan content was measured biochemically and histochemically. Reduced articular cartilage thickness in the MR images of papain-treated knees corresponded to changes in cartilage proteoglycan content.

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