doi: 10.1016/j.bmcl.2009.11.104.
Epub 2009 Nov 26.
Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents
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- PMID: 20005100
- DOI: 10.1016/j.bmcl.2009.11.104
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Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents
Bioorg Med Chem Lett.
.
Abstract
Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.
Copyright 2009 Elsevier Ltd. All rights reserved.
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