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. 2010 Jan 15;20(2):541-5.
doi: 10.1016/j.bmcl.2009.11.104. Epub 2009 Nov 26.

Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents

Myung Yun Lee  1 , Myung Hee Kim, Jinho Kim, Seok Hwan Kim, Bum Tae Kim, In Howa Jeong, Sukbok Chang, Seong Hwan Kim, Sung-Youn Chang
Affiliations

Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents

Myung Yun Lee et al. Bioorg Med Chem Lett. .

Abstract

Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.

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