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. 2010 Jan 15;20(2):465-8.
doi: 10.1016/j.bmcl.2009.11.117. Epub 2009 Nov 27.

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain

Robert J Gleave  1 , Paul J Beswick, Andrew J Brown, Gerard M P Giblin, Paul Goldsmith, Carl P Haslam, William L Mitchell, Neville H Nicholson, Lee W Page, Sadhana Patel, Susan Roomans, Brian P Slingsby, Martin E Swarbrick
Affiliations

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain

Robert J Gleave et al. Bioorg Med Chem Lett. .

Abstract

A series of 3-amino-6-aryl-pyridazines have been identified as CB(2) agonists with high efficacy and selectivity against the CB(1) receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which led to the identification of pyridazine analogue 35, a compound with high potency in an in vivo model of inflammatory pain.

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