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. 2010 Jan 15;20(2):767-70.
doi: 10.1016/j.bmcl.2009.11.011. Epub 2009 Nov 12.

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates

Amanda J Krzysiak  1 , Animesh V Aditya, James L Hougland, Carol A Fierke, Richard A Gibbs
Affiliations

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates

Amanda J Krzysiak et al. Bioorg Med Chem Lett. .

Abstract

Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology.

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Figures

Figure 1
Figure 1
Prenylation (either farnesylation by FTase or geranylgeranylation by GGTase-I) of Ras-related proteins, and subsequent processing events.
See this image and copyright information in PMC

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