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Comment
. 2009 Dec 11;139(6):1051-3.
doi: 10.1016/j.cell.2009.11.036.

Females battle to suppress their inner male

Andrew Sinclair  1 , Craig Smith
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Free article
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Females battle to suppress their inner male

Andrew Sinclair et al. Cell. .
Free article

Abstract

Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

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