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. 2009 Dec 11;36(5):715-9.
doi: 10.1016/j.molcel.2009.11.030.

Reverse transcribing the code for chromosome stability

Steven E Artandi  1 , Julia Promisel Cooper
Affiliations
Free article

Reverse transcribing the code for chromosome stability

Steven E Artandi et al. Mol Cell. .
Free article

Abstract

The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.

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