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Review
. 2010 Feb;20(1):87-90.
doi: 10.1016/j.gde.2009.11.002. Epub 2009 Dec 16.

Targeting the PI3K signaling pathway in cancer

Kwok-Kin Wong  1 , Jeffrey A Engelman, Lewis C Cantley
Affiliations
Review

Targeting the PI3K signaling pathway in cancer

Kwok-Kin Wong et al. Curr Opin Genet Dev. 2010 Feb.

Abstract

The phosphoinositide 3-kinase (PI3K) pathway is activated in a variety of different human cancers, and inhibitors of this pathway are under active development as anti-cancer therapeutics. In this review, we discuss the data supporting the use of PI3K pathway inhibitors in genetically and clinically defined cancers. This review focuses on their efficacy as single agents and in combination with other targeted therapies, specifically those targeting the MEK-ERK signaling pathway.

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Figures

Figure 1
Figure 1
Schematic of how the PI3K-AKT and MEK-ERK pathways regulate apoptosis in EGFR driven cancers.
See this image and copyright information in PMC

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